A team of University of British Columbia (UBC) researchers has discovered that insulin from the oral insulin tablets they are developing is absorbed by rats in the same way that injected insulin is.
The UBC team has developed a tablet that isn’t made for swallowing, but instead dissolves when placed between the gum and cheek. This method makes use of the thin membrane found within the lining of the inner cheek and back of the lips and was found to deliver all of the insulin to the liver without wasting or decomposing any insulin along the way. Similar to rapid-acting insulin injection, the UBC oral delivery tablet absorbs after only half an hour and can last for about two to four hours.
“These exciting results show that we are on the right track in developing an insulin formulation that will no longer need to be injected before every meal, improving the quality of life, as well as mental health, of more than nine million Type 1 diabetics around the world.” said Professor Dr. Anubhav Pratap-Singh, the principal investigator from the faculty of land and food systems.
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