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Oral insulin pill possible

Oral Insulin Pill Possible

Nadav Kidron, CEO of Oramed Pharmaceuticals, shows an insulin pill as he poses for a photo at the company’s offices in Jerusalem September 29, 2013. REUTERS/Baz Ratner

As reported by Reuters, tiny Israeli drugmaker Oramed Pharmaceuticals Inc on Wednesday said its experimental oral insulin succeeded in significantly reducing night-time blood glucose in patients with type 2 diabetes, according to initial data from a midstage trial.

The result is likely to surprise many sceptics who did not believe insulin could be delivered orally because they doubted it could survive the onslaught of digestive juices so it could have the intended effect. Oramed uses a protective coating and a high-enough dose of insulin so that most of it can be destroyed and still deliver a clinically beneficial amount of the hormone.

The positive results must be replicated in a larger Phase III trial before the drug, known as ORMD-0801, can be submitted for approval. But the data from the Phase II, 180-patient trial represents a major milestone.

While insulin is typically associated with Type 1 diabetes, many patients with Type 2 eventually see their disease progress to the point where they need insulin. Type 2 accounts for more than 90% of the nearly 400 million people with diabetes worldwide.
A safe and effective oral insulin, if approved, is expected to become a multibillion-dollar product. The main attraction of an insulin pill, aside from avoiding injections, is that it comes much closer to the path of natural insulin, which is produced in the pancreas and goes directly to the liver. ORMD-0801 goes from the gut to the liver, while injected insulin circulates throughout the body before it gets there. http://reut.rs/22g3vBj


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